Methods
- Fixed-effect model with stepwise (period) adjustment
- Fixed-effect model with linear adjustment
- Mixed-effect model with stepwise (period) adjustment
- Local regression (LOESS)
- Generalized additive model with P-splines
- Kernel regression
Fitted values - linear
trend

Control response over
time


Fitted values -
inverted-U trend

Control response over
time


Center for Medical Statistics, Informatics and Intelligent Systems,
Medical University of Vienna.
[Klassifizierung: vertraulich]
Marta Bofill Roig
marta.bofillroig@meduniwien.ac.at
and Pavla Krotka
pavla.krotka@meduniwien.ac.at